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\n\u535a\u7269\u9986\u5360\u5730\u9762\u79ef2000\u4f59\u5e73\u65b9\u7c73\uff0c\u76ee\u524d\u9986\u5185\u6536\u85cf\u4e86\u6765\u81ea\u8d8a\u5357\u3001\u6d77\u5357\u3001\u5370\u5c3c\u3001\u9a6c\u6765\u897f\u4e9a\u7b49\u4ea7\u9999\u533a\u7684\u6c89\u9999\u85cf\u54c1300\u4f59\u4ef6\uff1b\u5f53\u4ee3\u5de5\u827a\u7f8e\u672f\u5927\u5e08\u7684\u4f5c\u54c1\u6570\u5341\u4ef6\uff1b\u5386\u4ee3\u9999\u5177\u9999\u7089\u85cf\u54c1\u7b4950\u4f59\u4ef6\uff0c\u8be6\u5c3d\u5730\u5c55\u73b0\u4e86\u4ece\u53e4\u81f3\u4eca\u4e2d\u56fd\u4f20\u7edf\u9999\u6587\u5316\u7684\u53d1\u5c55\u5386\u53f2\u3002<\/p>\n

<\/p>\n

\u7b2c\u4e09\u4e2a\u91c7\u8bbf\u70b9\u662f\u91cd\u5e86\u6297\u6218\u5175\u5668\u5de5\u4e1a\u65e7\u5740\u516c\u56ed\uff1b\u91cd\u5e86\u6297\u6218\u5175\u5de5\u65e7\u5740\u516c\u56ed\u9879\u76ee,\u4f4d\u4e8e\u4e5d\u9f99\u5761\u533a\u8c22\u5bb6\u6e7e\u4ed8\u5bb6\u6c9f\u7247\u533a(\u539f\u91cd\u5e86\u5efa\u8bbe\u5de5\u4e1a\u96c6\u56e2\u5382\u5740),\u5360\u5730300\u4f59\u4ea9,\u7531\u91cd\u5e86\u5e02\u4e5d\u9f99\u5761\u533a\u653f\u5e9c\u4e0e\u56db\u5ddd\u5b89\u4ec1\u5efa\u5ddd\u6587\u5316\u4ea7\u4e1a\u5f00\u53d1\u6709\u9650\u516c\u53f8\u5171\u540c\u5f00\u53d1\u6253\u9020\u3002<\/p>\n

\u8be5\u9879\u76ee\u5206\u4e24\u671f\u5efa\u8bbe,\u4e00\u671f\u4e3a\u91cd\u5e86\u5efa\u5ddd\u535a\u7269\u9986\u3001\u6297\u6218\u5175\u5de5\u8857\u3001\u56fd\u9632\u5175\u5668\u6587\u5316\u4e3b\u9898\u516c\u56ed\u548c\u8336\u6587\u5316\u4e3b\u9898\u516c\u56ed4\u4e2a\u529f\u80fd\u533a,\u603b\u6295\u8d4412.97\u4ebf\u5143(\u5176\u4e2d\u6587\u726911\u4ebf\u5143\u8ba1\u52122018\u5e74\u5efa\u6210;\u4e8c\u671f\u671f\u4e3a\u6587\u5316\u521b\u610f\u4ea7\u4e1a\u56ed,\u8ba1\u52122018\u5e74\u5f00\u5de5\u5efa\u8bbe,2020\u5e74\u5b8c\u6210\u3002<\/p>\n

\u5927\u5bb6\u5bf9\u9986\u957f\u6a0a\u5efa\u5ddd\u5148\u751f\u90fd\u4e0d\u964c\u751f\uff0c\u4ed6\u5728\u5b89\u4ec1\u53e4\u9547\u5df2\u5efa\u6210\u6297\u6218\u3001\u7ea2\u8272\u5e74\u4ee3\u3001\u5730\u9707\u3001\u6c11\u4fd7\u56db\u5927\u7cfb\u521720\u4f59\u5ea7\u535a\u7269\u9986\uff0c\u5171\u6536\u85cf\u6587\u7269800\u4f59\u4e07\u4ef6,\u5176\u4e2d\u56fd\u5bb6\u4e00\u7ea7\u6587\u7269404\u4ef6\u3002<\/p>\n

<\/p>\n

\u5f53\u5929\u4e0b\u5348\uff0c\u91c7\u8bbf\u56e2\u4e58\u8f66\u524d\u5f80\u91cd\u5e86\u7cbe\u51c6\u751f\u6280\u672f\u6709\u9650\u516c\u53f8\uff1b\u91cd\u5e86\u7cbe\u51c6\u751f\u7269\u6280\u672f\u6709\u9650\u516c\u53f8\u603b\u90e8\u4f4d\u4e8e\u91cd\u5e86\u5e02\u9ad8\u65b0\u533a\u9ad8\u79d1\u521b\u4e1a\u56ed\u533a\u5185\uff0c\u7ec4\u5efa\u4e86\u91cd\u5e86\u7cbe\u51c6\u751f\u7269\u4ea7\u4e1a\u6280\u672f\u7814\u7a76\u9662\u3002\u516c\u53f8\u4e00\u671f\u5efa\u7b51\u9762\u79ef\u8fbe6000\u5e73\u7c73\uff0c\u8d2d\u7f6e\u5404\u7c7b\u9ad8\u7cbe\u5c16\u7814\u53d1\u4eea\u5668\u8bbe\u5907880\u591a\u53f0\u5957\u3002\u62e5\u6709\u7b26\u5408GLP\u89c4\u8303\u7684\u57fa\u7840\u7814\u53d1\u5e73\u53f0\uff0c\u4e0b\u8bbe\u5206\u5b50\u4e0e\u75c5\u6bd2\u7814\u53d1\u4e2d\u5fc3\u3001\u7ec6\u80de\u8f7d\u4f53\u6280\u672f\u7814\u53d1\u4e2d\u5fc3\u3001\u6297\u4f53\u5f00\u53d1\u4e2d\u5fc3\u3001\u4f53\u5916\u7ec6\u80de\u5b66\u529f\u80fd\u8bc4\u4ef7\u4e2d\u5fc3\u3001\u4f53\u5185\u52a8\u7269\u7597\u6548\u8bc4\u4ef7\u4e2d\u5fc3\u7b49\uff0c\u51715\u5927\u529f\u80fd\u6a21\u5757\uff0c\u5e76\u8bbe\u6709\u72ec\u7acb\u7684\u6280\u672f\u4e34\u5e8a\u8f6c\u5316\u5e73\u53f0\uff0c\u89e3\u51b3\u57fa\u7840\u7814\u53d1\u6280\u672f\u7684\u6807\u51c6\u5316\u3001\u89c4\u6a21\u5316\u9700\u6c42\uff0c\u8854\u63a5\u4e0b\u6e38\u4e34\u5e8a\u6280\u672f\u5e94\u7528\uff1b\u4e34\u5e8a\u5e94\u7528\u65b9\u9762\uff0c\u516c\u53f8\u5efa\u8bbe\u67092000\u5e73\u65b9\u7c73\u7684cGMP\u4e34\u5e8a\u4ea7\u54c1\u751f\u4ea7\u5236\u5907\u5e73\u53f0\uff0c\u4e0b\u8bbe\u4e34\u5e8a\u7ea7\u7ec6\u80de\u751f\u4ea7\u4e2d\u5fc3\u3001\u4e34\u5e8a\u7ea7\u75c5\u6bd2\u8f7d\u4f53\u751f\u4ea7\u4e2d\u5fc3\u3001\u4e34\u5e8a\u7ea7\u8d28\u7c92\u751f\u4ea7\u4e2d\u5fc3\u7b49\uff0c3\u5927\u72ec\u7acb\u529f\u80fd\u6a21\u5757\uff1b\u6b64\u5916\uff0c\u516c\u53f8\u8fd8\u5efa\u8bbe\u6709\u903e1000\u5e73\u65b9\u7c73\u7684\u8d28\u63a7\u68c0\u6d4b\u5e73\u53f0\uff0c\u4e0b\u8bbe\u57fa\u56e0\u8bca\u65ad\u4e2d\u5fc3\u3001\u7ec6\u80de\u5236\u54c1\u68c0\u6d4b\u4e2d\u5fc3\u548c\u751f\u7269\u6837\u672c\u5e93\u3002<\/p>\n

<\/p>\n

\u636e\u516c\u53f8\u526f\u603b\u7ecf\u7406\u5468\u6b63\u519b\u4ecb\u7ecd\uff0c\u91cd\u5e86\u7cbe\u51c6\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u548c\u6280\u672f\u5f15\u8fdb\uff0c\u5df2\u62e5\u6709\u7cbe\u51c6\u533b\u7597\u548c\u751f\u7269\u6cbb\u7597\u9886\u57df\u5173\u952e\u6838\u5fc3\u6280\u672f\uff08\u57fa\u56e0\u68c0\u6d4b\u3001\u57fa\u56e0\u7f16\u8f91\u3001\u4e34\u5e8a\u7ea7\u7ec6\u80de\u3001\u8d28\u7c92\u548c\u6162\u75c5\u6bd2\u751f\u4ea7\u6280\u672f\uff0c\u6297\u4f53\u9ad8\u901a\u91cf\u7b5b\u9009\u548c\u4eba\u6e90\u5316\u6539\u9020\u6280\u672f, \u9ad8\u8bb0\u5fc6\u6027CAR-T\u7ec6\u80de\u751f\u4ea7\u6280\u672f\uff0c\u80bf\u7624\u5e72\u7ec6\u80de\u9776\u5411\u6027CAR-T\u7ec6\u80de\u6280\u672f\uff0c\u4ee5\u53ca\u65b0\u578b\u514d\u75ab\u6291\u5236\u62b5\u6297\u578bCAR-T\u7ec6\u80de\u6280\u672f\u7b49\u7cfb\u5217\uff09\uff0c\u5e76\u5728\u5f02\u4f53CAR-T\u7ec6\u80de\u3001\u5fae\u73af\u5883\u8bf1\u5bfc\u578bCAR-T\u7ec6\u80de\u7b49\u751f\u7269\u533b\u836f\u56fd\u9645\u524d\u6cbf\u6280\u672f\u9886\u57df\u6709\u4e86\u91cd\u5927\u7a81\u7834\u3002
\nCAR-T\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\uff0c\u5df2\u6210\u529f\u7684\u7528\u4e8e\u767d\u8840\u75c5\u3001\u6dcb\u5df4\u7624\u3001\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3001\u80c3\u764c\u3001\u80a0\u764c\u3001\u80ba\u764c\u3001\u4e73\u817a\u764c\u3001\u80f0\u817a\u764c\u7b49\u591a\u79cd\u80bf\u7624\u7684\u6cbb\u7597\uff0c\u5176\u4e2d10\u4e2a\u9776\u70b9\u5df2\u901a\u8fc7\u4f26\u7406\u5ba1\u6279\u5e76\u5728\u56fd\u9645\u4e34\u5e8a\u7814\u7a76\u673a\u6784Clinical Trail\u8fdb\u884c\u4e86\u6ce8\u518c\uff1b CEA\u6cbb\u7597\u76f4\u7ed3\u80a0\u764c\u809d\u8f6c\u79fb\u5728\u7814\u4ea7\u54c1\u6280\u672f\u4e34\u5e8a\u6709\u6548\u7387\u83b7\u5f97\u56fd\u9645\u9876\u7ea7\u6743\u5a01\u671f\u520a\u8ba4\u53ef\u3002<\/p>\n

<\/p>\n

\u53c2\u89c2\u9686\u946b\u5de5\u4e1a\u56ed\u3002<\/p>\n

\u9686\u946b\u4e8b\u4e1a\u521b\u59cb\u4eba\u3001\u9686\u946b\u63a7\u80a1\u6709\u9650\u516c\u53f8\u8463\u4e8b\u5c40\u4e3b\u5e2d\u6d82\u5efa\u534e\u5148\u751f\u662f\u5168\u56fd\u5de5\u5546\u8054\u6267\u59d4\u3001\u5e38\u59d4\uff0c\u91cd\u5e86\u5e02\u5de5\u5546\u8054\u4e3b\u5e2d\u3001\u603b\u5546\u4f1a\u4f1a\u957f\uff0c\u5e76\u5f53\u9009\u4e3a\u7b2c\u5341\u4e09\u5c4a\u5168\u56fd\u653f\u534f\u59d4\u5458\uff0c\u7b2c\u5341\u4e00\u5c4a\u3001\u7b2c\u5341\u4e8c\u5c4a\u5168\u56fd\u4eba\u5927\u4ee3\u8868\u3002\u6d82\u5efa\u534e\u4e3b\u5e2d\u5148\u540e\u8363\u83b7\u5168\u56fd\u201c\u4f18\u79c0\u4e2d\u56fd\u7279\u8272\u793e\u4f1a\u4e3b\u4e49\u4e8b\u4e1a\u5efa\u8bbe\u8005\u201d\u3001\u201c\u5168\u56fd\u52b3\u52a8\u6a21\u8303\u201d\u3001\u201c\u5168\u56fd\u4f18\u79c0\u4f01\u4e1a\u5bb6\u201d\u3001\u201c2017\u5e74\u5ea6\u4e2d\u56fd\u4f01\u4e1a\u5341\u5927\u4eba\u7269\uff08\u6c11\u8425\u4f01\u4e1a\uff09\u201d\u7b49\u8363\u8a89\u3002<\/p>\n

<\/p>\n

\u9686\u946b\u901a\u7528\u7684\u65e0\u4eba\u76f4\u5347\u673a\u7531\u73e0\u6d77\u9686\u534e\u76f4\u5347\u673a\u79d1\u6280\u6709\u9650\u516c\u53f8\u7814\u5236\uff0c\u673a\u8eab\u91cd230\u516c\u65a4\uff0c\u8f7d\u91cd70\u516c\u65a4\uff0c\u7eed\u822a1\u5c0f\u65f6\uff0c\u8fd9\u4e9b\u6307\u6807\u5747\u5728\u76ee\u524d\u56fd\u5185\u884c\u4e1a\u9886\u5148\u7684\u3002\u9686\u534e\u4e13\u4e1a\u7ea7\u65e0\u4eba\u76f4\u5347\u673a\u662f\u9686\u946b\u901a\u7528\u4e0e\u6e05\u534e\u5927\u5b66\u4ea7\u5b66\u7814\u6df1\u5ea6\u5408\u4f5c\u7684\u6210\u529f\u4f8b\u5b50\u3002\u4ee5\u9686\u946b\u7684\u5fc3\u810f\uff08\u63d0\u4f9b\u52a8\u529b\u7cfb\u7edf\uff09\u3001\u6e05\u534e\u7684\u5927\u8111\u548c\u7fc5\u8180\uff08\u63d0\u4f9b\u98de\u63a7\u7cfb\u7edf\uff09\u76f8\u878d\u5408\u3002\u73b0\u5728\uff0c\u9686\u534e\u65e0\u4eba\u76f4\u5347\u673a\u5df2\u7ecf\u5f00\u53d1\u51fa\u6c11\u7528\u3001\u519b\u7528\u3001\u8b66\u7528\u4e09\u5927\u7cfb\u5217\u30022017\u5e749\u6708\uff0c\u6c11\u7528\u7684XV-2\u65e0\u4eba\u690d\u4fdd\u673a\u5728\u9752\u6d77\u6210\u529f\u5b8c\u6210\u6d77\u62d44120\u7c73\u7684\u9ad8\u539f\u5730\u533a\u65e0\u5730\u6548\u60ac\u505c\u6027\u80fd\u6d4b\u8bd5\uff0c\u73b0\u5df2\u5b9e\u73b0\u4e86\u6536\u5165\u7a81\u7834\uff0c\u5728\u9ed1\u9f99\u6c5f\u3001\u65b0\u7586\u7b49\u5730\u5f00\u5c55\u690d\u4fdd\u4f5c\u4e1a\uff0c\u5e76\u901a\u8fc7\u201c\u65e0\u4eba\u673a+\u4fe1\u606f\u5316\u201d\uff0c\u5728\u5f00\u5c55\u73b0\u4ee3\u519c\u4e1a\u5b9e\u73b0\u7cbe\u51c6\u690d\u4fdd\u7684\u540c\u65f6\uff0c\u63a8\u52a8\u519c\u4e1a\u5927\u6570\u636e\u91c7\u96c6\u548c\u5229\u7528\u3002\u9686\u534e\u65e0\u4eba\u673a\u4ea7\u54c1\u5728\u7b2c\u5341\u4e03\u5c4a\u5317\u4eac\u56fd\u9645\u822a\u7a7a\u5c55\u4e0a\u4eae\u76f8\u3002\u8fd9\u6bb5\u65f6\u95f4\uff0c\u4e2d\u56fd\u5175\u5668\u79d1\u5b66\u7814\u7a76\u9662\u4e3b\u529e\uff0c\u4e5d\u9f99\u5761\u533a\u653f\u5e9c\u534f\u529e\u76842018\u5e74\u4e2d\u56fd\u667a\u80fd\u88c5\u5907\u519b\u6c11\u4e24\u7528\u8bba\u575b\u66a8\u535a\u89c8\u4f1a\u6b63\u5728\u91cd\u5e86\u60a6\u6765\u56fd\u9645\u4f1a\u8bae\u4e2d\u5fc3\u53ec\u5f00\uff0c\u9686\u534e\u901a\u7528\u578b\u65e0\u4eba\u76f4\u5347\u673aXV-3\u53c2\u52a0\u6b64\u6b21\u535a\u89c8\u4f1a\uff0c\u5e76\u5f15\u53d1\u5f3a\u70c8\u5173\u6ce8\u3002\u91cd\u5e86\u5e02\u5e02\u957f\u5510\u826f\u667a\u7b49\u4e00\u884c\u53c2\u89c2\u901a\u7528\u578b\u65e0\u4eba\u76f4\u5347\u673aXV-3\uff0c\u8be6\u7ec6\u4e86\u89e3\u8be5\u6b3e\u65e0\u4eba\u673a\u7684\u7814\u53d1\u548c\u751f\u4ea7\u8fdb\u5ea6\uff0c\u5e76\u5bf9XV-3\u5728\u8b66\u7528\u3001\u519b\u7528\u3001\u53cd\u6050\u53ca\u5b89\u4fdd\u7b49\u9886\u57df\u53d1\u6325\u7684\u4f5c\u7528\u8868\u793a\u671f\u5f85\u3002
\n\u524d\u5f80\u534e\u5ca9\u5fd7\u613f\u670d\u52a1\u4e3b\u9898\u516c\u56ed\uff1b<\/p>\n

2018\u5e743\u67084\u65e5\uff0c\u516c\u56ed\u5efa\u6210\u5f00\u56ed\uff0c\u5e76\u5f00\u5c55\u4e86\u201c\u5411\u6625\u5929\u62a5\u5230\u201d\u91cd\u5e86\u5e02\u201c3.5\u201d\u5b66\u96f7\u950b\u65e5\u4e3b\u9898\u5fd7\u613f\u670d\u52a1\u6d3b\u52a8\u3002<\/p>\n

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